GLP-1 therapy is one of the biggest advances in weight management in a generation. Sheba delivers it with something most services don't, a doctor who understands women's hormones, not just the number on the scales.
Average body weight lost with GLP-1 therapy over 68 weeks in clinical trials
More effective than diet and exercise alone for women with PCOS
Improvement in how the body handles blood sugar in women with hormonal weight gain
All treatment plans reviewed and prescribed by a Doctor. Results vary by individual.
For many women, weight isn't just a calories-in, calories-out problem. Hormones change everything — they affect where your body stores fat, how hungry you feel, and how you respond to treatment.
"The same medication, given to two women, can produce completely different results."
Sheba pairs GLP-1 therapy with a clinical team that actually understands this. Your treatment is built around your hormonal picture, not just your BMI. It's the difference between a prescription and a programme.
If your BMI meets the clinical threshold for GLP-1 therapy, Sheba is for you — with or without an underlying condition. The conditions below explain how we go deeper for women who have additional hormonal factors at play.
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These conditions create specific hormonal barriers that standard programmes never address.
If you have PCOS, you've probably been told to eat less and move more and found it just doesn't work. That's not a willpower problem. PCOS creates a hormonal cycle where weight gain makes the condition worse, and the condition makes weight gain harder to shift. It becomes self-reinforcing in a way that diet alone can't break.
GLP-1 therapy addresses the metabolic dysregulation driving insulin resistance. It works with your biology, not against it.
Many women reach their forties or fifties and find their body has changed in ways that feel completely outside their control. Weight moves to the middle. You feel full less easily. Things that used to work stop producing results. This isn't a lack of effort, it's a hormonal shift that fundamentally changes how your body manages weight.
GLP-1 restores the signals that tell your body when you're full and how to use energy, signals that falling oestrogen disrupts. Combined with hormone support, results go significantly further.
If you're preparing for IVF or other fertility treatment, reaching a healthy weight beforehand can make a real difference, some studies suggest it can double the likelihood of successful implantation. But when PCOS or hormonal imbalance is involved, that target can feel genuinely out of reach through lifestyle changes alone.
Why GLP-1 works hereSheba's pre-fertility pathway is built alongside fertility specialists focused on reaching your target safely and at the right pace ahead of treatment.
Women often experience the early signs of type 2 diabetes very differently such as persistent tiredness, brain fog, weight that shifts without obvious reason. These get dismissed or chalked up to stress. And because hormonal changes through the cycle and menopause affect blood sugar directly, standard management often misses the full picture.
Why GLP-1 works hereGLP-1 medications were originally developed to treat type 2 diabetes. The evidence is some of the strongest available and Sheba adds the hormonal context most services miss.
Many Sheba patients don't have a named condition. They've just tried... really tried and weight loss hasn't happened the way it's supposed to. GLP-1 therapy is clinically effective for weight management in its own right, and Sheba provides it with the same level of care and monitoring as every other pathway.
What you getA full clinical assessment, a prescription from a consultant gynaecologist if appropriate, and ongoing monitoring — not just a medication posted to your door.
GLP-1 therapy is available from many services.
Here's what makes Sheba different at a comparable price.
Every Sheba prescription is reviewed by a doctor who understands how your hormones and metabolism interact. Not a questionnaire. Not a pharmacist. A doctor who can see the full picture.
Your treatment accounts for where you are hormonally, your cycle, your menopause status, any underlying conditions. Built around your body, not a standard dose sent in the post.
Regular clinical check-ins, blood work where needed, and adjustments if something isn't working. You're not left managing side effects or plateaus on your own.
From clinical protocols to the way we communicate. everything here is designed with women in mind, not adapted from research conducted on predominantly male cohorts.
GLP-1 medications are licensed, well-studied, and have been used clinically for over a decade. Side effects — usually mild nausea or digestive changes — are most common in the first few weeks as your body adjusts. Our clinical team monitors you throughout. No prescription is issued without a full medical review first.
No. GLP-1 therapy works best as a tool for reaching a healthy weight and building sustainable habits alongside it. Some patients come off it when they reach their goal. Others continue at a lower maintenance level. Your Sheba doctor will guide you through what makes sense for you specifically — not a one-size answer.
Yes, absolutely. You don't need PCOS, a thyroid condition, or any diagnosis. If your BMI meets the clinical threshold — typically 30+, or 27+ with a relevant health factor — you're eligible. The eligibility banner above explains this in more detail.
Most online services use a nurse prescriber or an automated questionnaire. Every Sheba prescription is reviewed by a consultant gynaecologist who understands women's hormonal health — not just BMI. Your protocol is tailored to your hormonal picture, with ongoing monitoring included as standard.
Sheba is comparable in price to other GLP-1 services — but includes consultant gynaecologist oversight, hormone-aware protocols, and ongoing clinical monitoring that most services charge separately for, or don't offer at all. Full pricing is available on our plans page.
These conditions sit within our clinical scope but require more careful framing. We'll always be straightforward about what we can offer — and where your existing specialist care should lead.
Take our 5-minute assessment.
A Doctor reviews your full picture and tells you honestly which pathway makes sense.
Reviewed by a doctor before any prescription. No commitment required.
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